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SelfDecode does not treat, diagnose or cure any conditions, 3. (14, 15). A study with four groups of 30 patients each were studied: (1) systemic Pycnogenol and local application; (2) local Pycnogenol only; (3) oral Pycnogenol and (4) medications only (control). DOI: Marini A, et al. A study of 68 people found that Pycnogenol, started 2 days prior to flying, may reduce the duration of jet lag symptoms [83]. Pycnogenol may stimulate the immune system. A trial of 39 people with hay fever found that Pycnogenol may reduce nose and eye symptoms. is a clickable link to peer-reviewed scientific studies. Seems like it must be pretty amazing, but lets look closer. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months. Moreover, Pycnogenol treatment led to an increase in sperm count and testosterone levels with lowering of blood pressure and cholesterol levels. In one study, people with high blood pressure were examined to see how the supplement impacted their blood pressure. In one study, 200 mg a day of Pycnogenol taken three hours prior to the first cigarette for the day for two months significantly reduced cigarette-induced platelet aggregation. A total of 40 patients with retinopathy (damage to the retina part of the eye) from diabetes and other vascular causes were enrolled in one study. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. Some research suggests that procyanidins may have antioxidant and anti-inflammatory activity. DOI: Gulati OP. Pycnogenol (125 mg/day) had the same effects in another study of 48 people with diabetes and high blood pressure. . Diabetic retinopathy is a type of eye injury caused by complications from diabetes. Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. DOI: Dvorkov M, et al. Another study in 2012 showed that Pycnogenol alone, at a dose of 75 mg/day, increased skin hydration by 8% after just 6 weeks; in women with dry skin at baseline the increase was 21%. It also slightly decreased blood pressure and increased testosterone [67]. Pycnogenol was gradually increased to 120 mg/day over this time period, while the l-arginine was maintained at 1.7 g/day throughout. While much of this is positive, it will be a while before doctors routinely recommend this dietary supplement for these conditions. (4). A study of 50 mildly infertile men found that a combination of L-arginine, L-citrulline, roburins, and Pycnogenol (Prelox R) may improve sperm quality, volume, and concentration [75]. However, these studies appear to be methodologically sound and reliable, with no blatant errors in the study design and data collection. However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. What gives pine bark extract its notoriety as a powerful ingredient and super antioxidant is that its loaded with oligomeric proanthocyanidin compounds, OPCs for short. Pine bark distill has been studied regarding its relationship to exercise performance, oxidative stress and excitement to torso that has been imposed by exercise. 5) Vein Diseases and Swelling. When pycnogenol cream was added to oral supplements in a small study of 18 people with vein ulcers, it helped ulcers heal more quickly [26]. Another highlight of grapes nutrition is the presence of polyphenols, which have been shown to decrease chronic inflammation. Pycnogenol in metabolic syndrome and related disorders [Abstract]. In a study of 77 people with symptoms of Irritable Bowel Syndrome (IBS), Pycnogenol (150 mg/day) improved symptoms and reduced the frequency of attacks [77]. L-arginine is more effective when paired with L-citrulline or pycnogenol to combat erectile dysfunction and improve exercise performance. Lutein uses and benefits include helping prevent eye conditions like macular degeneration and cataracts, skin disorders and skin cancer, several types of cancer, including colon or breast cancer, type 2 diabetes, and heart disease. However, with the addition of twice-daily Pycnogenol, normal erection increased to 80%, which further increased to 92.5% during the third month on thrice-daily Pycnogenol. Add to Cart. Pycnogenol may reduce glucose levels, but it doesnt appear to increase insulin production or insulin sensitivity. This condition can be temporary or permanent however, some studies have indicated that pine bark extract may help alleviate these symptoms due to its high presence of antioxidants. Luckily, the Native Americans told them about a tea prepared from the bark of a certain tree, which miraculously led to complete recovery. One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. It may cause side effects such as: Risks. Pycnogenol has not been found to cause these issues however, it may take a little longer the feel the relief from pain than aspirin. A study of 147 people found that pycnogenol (100 mg/day) may improve running, push-ups, and sit-ups endurance in recreational athletes over an 8-week training program. One way to add some extra flavor and nutrients to your day is by adding prune juice to your diet. A good-quality study was conducted in 77 diabetic patients who received their standard antidiabetic treatment along with 100 mg Pycnogenol a day or placebo for 12 weeks. It can also be used for local application on the skin without the risk of side effects. However, a study of 24 adults with ADHD found that pycnogenol did not improve ADHD symptoms better than placebo. Pycnogenol seems well-tolerated for use in adults for up to 6 months. Taking pine bark extract also increases the blood . A combination product with Pycnogenol (Lady Prelox) improved sexual function in a clinical trial of 83 healthy postmenopausal women after 8 weeks. Dr. Eric L. Zielinski is a sought-after natural . (2017). A clinically studied blend of Pycnogenol and a special bilberry extract (called Mirtogenol ) has been shown to provide benefits for vision and eye health. 4. (10), A 15-year Dutch study was published stating that 27,939 healthy female health professionals were given aspirin or a placebo for a period of time. More research is needed to see how this supplement affects all of these conditions. Taking pycnogenol daily for 2 months seems to slow or prevent further worsening of retinal disease caused by diabetes, atherosclerosis, or other diseases. Our team includes licensed nutritionists and dietitians, certified health education specialists, as well as certified strength and conditioning specialists, personal trainers and corrective exercise specialists. Researchers suggest it may boost sustained attention, memory, executive functions, mood, and reduce oxidative stress [19]. Pine bark extract can make a great addition to your nutritional arsenal for its potent antioxidant support, as well as its added support for blood flow, blood sugar, inflammation, immunity, brain function and skin support. It can also stabilize mast cells, which release histamine and trigger allergic reactions. According to a meta-analysis of 9 trials including 549 people, 150-200 mg/day for at least 12 weeks may reduce both diastolic and systolic blood pressure [36]. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Pine bark extract can be found in liquid, tablet or capsule form containing 85 percent to 90 percent OPCs. Pain score in the Pycnogenol-treated group was reduced by 56%, as compared to 9.6% reduction in the placebo group. This article reviews tongkat ali, Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. Organika Pycnogenol 50mg 50 Tablets . In addition to OPC, grape seed extract contains linoleic acid, flavonoids and phenolic procyanidins that help protect and strengthen capillaries, blood vessels, veins and arteries, which can then improve blood circulation. The supplement significantly reduced hot flashes, night sweats, mood swings, irregular periods, loss of libido, and vaginal dryness. ", American Heart Association: Understanding Blood Pressure Readings., Iranian Journal of Public Health: "Effect of Pycnogenol Supplementation on Blood Pressure: A Systematic Review and Meta-analysis. Pycnogenol, an extract of French maritime pine bark, helps the body fight normal aging by supporting vascular health and healthy circulation. Inhibits platelet aggregation like low-dose aspirin. You should also avoid using pine bark extract without talking to your doctor first if you: You should also do additional research or talk to your doctor before taking pine bark extract if you also take: While pine bark extract is a natural supplement, it can have powerful effects on your health, both positive and negative. Symptoms include swelling in ankles and legs, discolored skin and, if the skin is broken, the development of leg ulcers. Infants and children may not be able to synthesize enough of it, but it is present in many protein-rich . The 2012 study on the anti-aging benefits of Pycnogenol is commonly-cited by anti-aging supplement manufacturers. Procyanidins are chain-like structures consisted of catechins similar to some found in green tea (the green tea catechins that do not have 'gallate' in their names). Ana has many years of experience in clinical research and health advising. Pycnogenol (100 mg/day) may reduce leg swelling, spider veins, and cramps according to a study of 133 women with varicose veins who recently gave birth. Thus, this powerful extract works as a natural ear infection remedy while improving balance and preventing hearing loss. High levels of both of these are considered risk factors for heart disease. There havent been any studies looking at long-term liver damage. Potential for allergy when taken orally or used on the skin. In one human study, some of the reported side effects of chanca piedra supplementation included: abdominal pain. Pycnogenol significantly reduced the swelling as well as the feeling of heaviness. A new peer-reviewed study, published in the Bratislava Medical Journal, shows that daily supplementation with the natural antioxidant, Pycnogenol, a French maritime pine bark extract, can improve the symptoms of ED.. The top benefits of nattokinase include the following: Regulate blood pressure. Pine bark extract offers some amazing benefits since its so high in powerful antioxidants. Pine bark extract has been studied regarding its relationship to exercise performance, oxidative stress and inflammation to body that has been imposed by exercise. It decreased concussion symptoms in 42 student-athletes with a history of sports-related concussions after 6 weeks. Ginkgo biloba has been widely cultivated across the globe for a variety of uses, most of which are medicinal. According to research, Pycnogenol may have a multitude of health benefits, which are likely due to this extracts antioxidant and anti-inflammatory properties.